ࡱ>  cXYZ[\]^_`ab@=/7AhP\-9>/  jxo$Wk&$]~UunLQ Jv#!ABD` Kl% ,x!!!!8[厓߹p]oU_[ ,'`+ǯ~y5^mwR! n|_|50({tDz͔߸o<_4,4iWƿ͗:%9I> >g= 1;yLKҗq?3'`w礔l_WSƣ| 6툼*sb;c y3*/;Xl3ۉؾb"+* Nۥ2V mH>Oh%}hʾ26Ť6'o/{lK:Ɯ ,m)'ttI='D䍩 1KD>K9X1}B)%mI y䞂NX*vH^v)O`lmw|b O{r>1})5okfs.ȫzoWt 9og䭩`mmە`lwKқ oʼc|&%ywT`ݙ^y j'+ ;^ROcّ6OXwA-',Lpy؞z:oo#^Ȉs& Ձ bת9Ah|σ↿07>3?l_6m 5mdb|gx*32|L 2mOׇeuOueTGmE΀WLzT?\)𥦟A'> I~۸ٖgF[NncA;6m߸tj{ٗ-zJH!<]~/YbD&wuV }<{tƽA7mOmҹ`_q6ǧOݘWѹjA#uuڮ_Ju ^_O6ߌ^SNa- `;:K%x?.Y@|.@ߑ6-h;%ɾ߈k8t}ZHAϟۇu}mo-LWNz}o8`NX:19wc)_DLPuU=߷y) /4\pRYxvʲNzk!3&%i&?ep^k1#neEby|@*z/mv_OS1>VF %<ՠ}5wScPSyzG+8NSOpUۧ5ƽ}5}\ ލ-79C#=k/ϲ'>}B4dSRc8b:bM,ﺳŚcGxrݧ8C ci}}0)ʁ/;\ kݝ|1X|P^Hsf1}ͅRAy d7|\$a^YH' c%YYv_MaS0Wj8l ֮66sCa2G,qqa-dJX9l |Ylk2,my ]gE̶k͑B^Q>QפbS#,y ]WodnȲk6 㼢1/iy Mi+uA~Uy!w~HbicM>}Ň..ZX)Z{lev1/ց,VP-@P0IYL ͚:.#fCkb^$ϋIK XL fDX2pmג4 X, >omz4S]<  G+'fSfB;Νg}EBӽzN̗JP5VxdO^LX>_kv#Ο0[!,0L.`Χ/ky+Yҵ1i"z<6|0[u'̶22ۄKMZ#{5̶ 8lkJfKbfA>Nz\~Ԉf e1 Epc4 0IDb.V1[j@{ȼM2SW yɩ3٘cmw[fҙN! gZF_,KY2!VD2Ɗ!c53CbOk3!FK'˟U .ŷŤ1i^C$,&ɟU4l}se9SW5d /ٰOh^R5{a0Xlg3w>v+PČ#@+T&þvG_,\ cHqlgcdll=ld3I^,,a,L%>5c4|OݧS+հHX5dVNul=ל2Jg Y3){fs:-{S9[m2Flc1m̦xlɕ=12[l9dV&&[C){b6H>휹-73 ,5nV-2r 8Jq %0I'\_ݷf(a6-~v/0*7\q3="O/l̙|B>Y˽WRym#|βsa?Lr!s ͟OwW (6.JIN[k:΍l_ 0W+7nc\i>Em*huHߘbki#Uc:F/od41I쾉b}UG;5Of쾳V2 ԗ𝵲IsFK[@;_,{$-HsOI ݷF+ЏHKݧ< `T9}9jR[V\9h|s9S37Ѧ|y 5P3>utIJ|H %$IIV0oW>\`Y{ff` R>&- {p_/̴>?" dd@,|?" dd@   " @ ` n?" dd@   @@``PR    @ ` ` p>> f(    6  `}  T Click to edit Master title style! !  0H  `  RClick to edit Master text styles Second level Third level Fourth level Fifth level!     S  0 ^ `  >*  0 ^   @*  0 ^ `  @*H  0޽h ? 3380___PPT10.#=< Default Design  "4(     <| UVamos a estudiar una reaccin en la que juntaremos dos pares Redox en un recipiente :.=      <੗0b  Aoxi + e-8   "  Z     A# "] T   c $X99?      BpCDE F*$!$!jJF>p >FF@`  t  < \  `Ared"  Z    # " JT  c $X99?     BpCDE F*$!$!jJF>p >FF@`  t  <>p  Boxi + e-8   "  Z    A# "^ 0T  c $X99?     BpCDE F*$!$!jJF>p >FF@`  t  <H j  `Bred"  Z    # " @ T   c $X99?   !  BpCDE F*$!$!jJF>p >FF@`  t " <×~ E0 = + 250 mV $ .     # <ȗ~ E0 = - 415 mV $.     $ 0͗ 0  En el primer par la forma oxidada tiene mucha afinidad por los electrones. En el segundo par la forma oxidada tiene poca afinidad por los electrones. Por lo tanto, si juntamos ambos pares en la misma cubeta en condiciones equimoleculares, la reaccin se realizar en la direccin :.  ,  % <8җ    Aoxi + Bred:   0   Z    &A# " n T ' c $X99?   (  BpCDE F*$!$!jJF>p >FF@`  tZ    *# " . ^ z T + c $X99?   ,  BpCDE F*$!$!jJF>p >FF@`  t& - <ݗ$ VEn que el par de menor potencial potencial Redox cede electrones al de mayor potencialH!    &  . < b0   Ared + Boxi:   0   l  3,$D 0`r / 02 2 <C"?@  ^e-$  s 4 <F Realizado por Dr. A. Martnez-Conde & Dra P. Mayor Dep. Bioqumica y Biologa Molecular Fac. Medicina Universidad Complutense de Madrid H&  /  , H  0޽h ? 33___PPT10e.#0<+pD9' = @B D' = @BA?%,( < +O%,( < +D+' =%(D' =%(D{' =4@BBB B%() A)))D' =1:Bvisible*o3>+B#style.visibility<*3%(D' =-w6Bdiamond(out)*<3<*3+9 PH`(    <a0P  Aoxi + Bred:   0   Z    A# "~PT  c $X99?     BpCDE F*$!$!jJF>p >FF@`  tZ    # "2>n T  c $X99?     BpCDE F*$!$!jJF>p >FF@`  t   <Th0r @P  Ared + Boxi:   0   =   0\q$ wLa diferencia entre el potencial Redox de ambos pares nos indica la direccin y grado de espontaneidad de la reaccin :xx.!  Q    <t@`' Par A E0 = + 250 mV $  .      <zS Par B E0 = - 415 mV $ .      <X0p * DE0 = + 665 mV 6  .    M  0|` 0   Como podemos expresar la espontaneidad de esta reaccin en trminos termodinmicos ?. Esto es, en trminos de Variacin de Energa libre Estandar"  I  0(0p oCuanto mayor ( y positiva ) sea la DE0 mas hacia la derecha estar desplazada esta reaccin en el equilibrio.Bp# Ho $  0 d  DG = - nF DE 8$ $$$V        0ș@  $Cuanto mayor y ms positiva es la diferencia de potencial Redox Estandar, menor y mas negativa es la Variacin de Energa libre Estandar.b:    9   s  <F Realizado por Dr. A. Martnez-Conde & Dra P. Mayor Dep. Bioqumica y Biologa Molecular Fac. Medicina Universidad Complutense de Madrid H&  /  , H  0޽h ? 33___PPT10i.#=I+D=' = @B +Y ph7$@(  $ $ 0ԨG ELa Ecuacin de Nernst nos permite calcular Potencial de Oxidacin-reduccin de una reaccin redox en condiciones reales conociendo las concentraciones de oxidantes y reductores :&H  G  R  $ <ȯ @ @  Aoxi + Bred:   0   Z    $A# " @T $ c $X99?   $  BpCDE F*$!$!jJF>p >FF@`  tZ    $# "" T $ c $X99?   $  BpCDE F*$!$!jJF>p >FF@`  t $ <P  @  Ared + Boxi:   0   $ $ 0 0  DG = - nF DE 8 V      8 0  /$0  $ 00Pp  DE = DE8 "  @   -$   $ 6R P  PRT  '$ 6  S_ ____  *$ B  PnF  .$ <`  @ PLn 8  P  3$P ` 1 0$ <X2P/p  [Ared][ Boxi]D  H     1 1$ <,@=   [Aoxi][ Bred]D  H      2$ <(  V __________     4$ <pp W  WSe pueden resumir las relaciones entre Variacin de Energa libre y Potencial redox : .N    5$ 0 p  DG = - nF DE 8 .   H $ 0޽h ? 33___PPT10i.$`+D=' = @B + -% !(   R 0`  # #"znkkkjkkkkkokkkokkkokkkjkkk0`   <N  ?"` `  B  @`   <U  ?"`   j0.00   @`   <^  ?"`  FADH2 ( en D-AA oxidasa ) *  @`   <g  ?"`  @  @`   Bhi  ?"`0  g FAD + 2 H+ + 2 e-   @`   <y ? `^ gI   @`   <؂ ?  ^ S- 0,030  @`   < ? ^ (Fe-S)red N-2 ( complejo I ) .    @`   < ?^ @  @`   B ?0^ (Fe-S)oxi N-2 + e-  .    @`   < ? `/ gI   @`   <@ ?  / o- 0,300   @`   <H ? / FMNH2 ( complejo I )   @`   <  ?"`/ @  @`   B  ?"`0/ bFMN + 2 H+ + 2 e-   @`   < ? `5  B  @`   < ? 5  T+ 0, 295    @`   < ? 5  NH2O2   @`   < ? 5  @  @`   B, ?0 5  ^O2 + 2 e- + 2 H+   @`   <" ? 5 `  hIV   @`   <" ? 5  S+ 0,385  @`   <" ?5  hemo a3 ( Fe++ ) (complejo IV )   $ @`   <8 " ?5   @  @`   B)" ?05   hemo a3 ( Fe+++ ) + e-   @`   <2" ? `g B  @`   <;" ? g R0,420  @`   <=" ? g YNO2- + H2O   @`   <M" ? g @  @`   BO" ?0 g bNO3- + 2 e- + 2 H+   @` !  <$`" ? g` B  @` "  <h" ? g  S+ 0,480  @` #  <Pr" ?g  PSO32-     @` $  <P{" ?g @  @` %  B0}" ?0g `SO42- + 2 e- + 2 H+   @` &  < " ? @  @` '  <" ?   @  @` (  <О" ?[   @  @` )  <" ? [  @  @` *  <ܰ" ?)   @  @` +  <" ? )  @  @` ,  <" ?^ @  @` -  <" ?, @  @` .  <" ?, @  @` /  <p" ? @  @` 0  <H" ?a @  @` 1  < " ?a @  @` 2  <" ?/ @  @` 3  <# ? @  @` 4  < # ?d @  @` 5  <# ?d @  @` 6  <# ?2 @  @` 7  <l%# ?2 @  @` 8  <8.# ? @  @` 9  <6# ?  MH2O   @` :  <09# ?  wcitocromo a ( Fe++ )     @` ;  < J# ?[  wcitocromo c ( Fe++ )     @`  <  <:# ? [  !hemo c1 ( Fe++ ) ( complejo III )"" $ @` =  <U# ?)   citocromo b ( Fe++ )( mitoc. ) !! $  @` >  <Pg# ? )  l ubiquinol      @` ?  <p# ?^  psuccinato-    @` @  <a# ?,  k malato-     @` A  <0|# ? , l lactato-     @` B  <D# ?  l etanol     @`  C  <|# ?a  FADH2 ( coenzima libre )  ,  @` D  <# ? a NSH2   @` E  <D# ?/  cido dihidrolipoico  $ @` F  <# ?  ONADH   @` G  <P# ?d  U NADPH   @` H  <# ? d x2 cisteina   @` I  <# ?2  b - hidroxibutirato- $   @` J  <$# ? 2 Q 1/2 H2     @` K  <@# ?  wacetaldehido + H2O     @` L  B # ?0 f1/2 O2 + 2 e-+ 2 H+   @` M  B# ?0   citocromo a ( Fe+++ ) + e-    @` N  BD$ ?0[   citocromo c ( Fe+++ ) + e-    @` O  B\ $ ?0 [  |hemo c1 ( Fe+++ ) + e-   @` P  B$ ?0)   citocromo b ( Fe+++ ) + e-    @` Q  B$ ?0 )  ubiquinona + 2 H+ + 2 e-    @` R  B$ ?0^ fumarato- + 2 H+ + 2 e-   @` S  B/$ ?0, oxalacetato- + 2 H+ + 2 e-    @` T  B9$ ?0,  piruvato- + 2 H+ + 2 e-   @` U  B;$ ?0 acetaldehido + 2 H+ + 2 e-    @` V  BPL$ ?0a bFAD + 2 H+ + 2 e-   @` W  B\U$ ?0a aS + 2 e- + 2 H+   @` X  BW$ ?0/  cido lipoico +2 H++ 2 e- !! $ @` Y  Bh$ ?0 bNAD+ + H+ + 2 e-   @` Z  BY$ ?0d dNADP+ + H+ + 2 e-   @` [  Bs$ ?0d |cistina+2 H++2 e-   @` \  B$ ?02 acetoacetato- + 2 H+ + 2 e-    @` ]  BL$ ?02 Z2 e- + 2 H+   @` ^  BT$ ?0 acetato- + 3 H+ + 3 e-   @` _  <$ ?   S+ 0,815  @` `  <4$ ?  S+ 0,290  @` a  <d$ ? [  S+ 0,254  @` b  <l$ ? [  S+ 0,220  @` c  <t$ ? )  S+ 0,077  @` d  <|$ ? )  S+ 0,045  @` e  <$ ? ^  S+ 0,031  @` f  <<$ ? ,  S- 0,166  @` g  <$ ?  , S- 0,185  @` h  <,$ ?   S- 0,197  @` i  <$ ? a  S- 0,219  @` j  <% ?  a S- 0,230  @` k  <$ ? /  S- 0,290  @` l  <% ?   S- 0,315  @` m  <% ? d  S- 0,320  @` n  <'% ?  d S- 0,340  @` o  <1% ? 2  ^- 0,346 $    @` p  <:% ? 2 S- 0,421  @` q  <D% ?  S- 0,581  @` r  <LM% ? ` hIV   @` s  <U% ? `  hIV   @` t  <_% ? [ `  nIII - IV     @` u  <i% ? `[  iIII   @` v  <q% ? ) `  iIII   @` w  <{% ? `)  ~ I,II - III   "   @` x  <% ? ^` hII   @` y  <܍% ? ,` B  @` z  <% ? `, B  @` {  <% ? ` B  @` |  <l% ? a` B  @` }  <% ? `a B  @` ~  <x% ? /` B  @`   < % ? ` gI   @`   <% ? d` B  @`   <% ? `d B  @`   <% ? 2` B  @`   <x% ? `2 B  @`   <D% ? ` B  @``B   0o ?00`B   0o ?``ZB   s *o ?ZB   s *o ?`B   0o ?0`B   0o ? `B   0o ?0`B   0o ? `B   0o ?002`B   0o ?020`B   0o ?00d`B   0o ?0d0`B   0o ?00`B   0o ?00`B   0o ?00a`B   0o ?0a0`B   0o ?00`B   0o ?00,`B   0o ?0,0`B   0o ?00`B   0o ?00) `B   0o ?0) 0 `B   0o ?0 0[ `B   0o ?0[ 0 `B   0o ?0 0 `B   0o ?0 05 `B   0o ?05 0 `B   0o ?0 0g`B   0o ?0g0`B   0o ?00`B   0o ? `B   0o ?  `B   0o ? `ZB   s *1 ? `ZB   s *1 ? 2`2ZB   s *1 ? `ZB   s *1 ? d`dZB   s *1 ? `ZB   s *1 ? `ZB   s *1 ? `ZB   s *1 ? a`aZB   s *1 ? `ZB   s *1 ? `ZB   s *1 ? ,`,ZB   s *1 ? `ZB   s *1 ? `ZB   s *1 ? ) `) ZB   s *1 ? ` ZB   s *1 ? [ `[ ZB   s *1 ? ` ZB   s *1 ? ` ZB   s *1 ? 5 `5 ZB   s *1 ? ` ZB   s *1 ? g`gZB   s *1 ? ``B   0o ? `ZB   s *1 ? /`/ZB   s *1 ? ^`^ZB   s *1 ? ` L `  # ZB   s *D@``ZB  B s *DL `  # >iZB   s *D@``ZB  B s *DL `  # ZB   s *D@``ZB  B s *DL `  # uZB   s *D@``ZB  B s *DL `  # ZB   s *D@``ZB  B s *DL `  # ZB   s *D@``ZB  B s *DL `  #  LZB   s *D@``ZB  B s *DL `  # ZB   s *D@``ZB  B s *DL `  # {ZB   s *D@``ZB  B s *DL `  # )ZB   s *D@``ZB  B s *DL `  # ZB   s *D@``ZB  B s *DL `  # .YZB   s *D@``ZB  B s *DL `  # ZB   s *D@``ZB  B s *DL `  # pZB   s *D@``ZB  B s *DL `  #   ZB   s *D@``ZB  B s *DL `  # p  ZB   s *D@``ZB  B s *DL `  #  , ZB   s *D@``ZB  B s *DL `  #   ZB   s *D@``ZB  B s *DL `  # I u ZB   s *D@``ZB  B s *DL `  #  "ZB   s *D@``ZB  B s *DL `  # ZB   s *D@``ZB  B s *DL `  #  , ZB ! s *D@``ZB !B s *Dx ! <& 7V  ! <&   * El potencial Redox estandar del FAD / FADH2 cuando est unido al enzima covalentemente vara entre  465 y +169 mV. ww b    -   L ` !#   ZB ! s *D@``ZB !B s *DL ` !# P | ZB ! s *D@``ZB  !B s *DL `  !# 0[ZB  ! s *D@``ZB  !B s *DRb  ! s *0 Xb ! 0pp Rb ! s *  Rb ! s *f `Rb ! s * p Rb ! s *f p`Xb ! 0p`  ! <#& p`0 RNADH  ! <(&  aFADH2$   ! 0,& P] g Succinato$      s ! <1& F Realizado por Dr. A. Martnez-Conde & Dra P. Mayor Dep. Bioqumica y Biologa Molecular Fac. Medicina Universidad Complutense de Madrid H&  /  ,  ! 06& p JLas distancias no son proporcionales a las diferencias de potencial redox.KK .D   2 ! <8;& C"?`p0  ^e-$  2 ! 6@& p@ QETF x ! <A ??R   ! <E& @ g b-oxidacin$    H  0޽h ? 33/'___PPT10.1;+Dk' = @B D&' = @BA?%,( < +O%,( < +D' =%(D' =%(Df' =A@BB*BB0B%(/%,( < +)?)?)Di' =.17 BBBBBCM 0.0 -3.33025E-6 L 0.0 0.76596 *3>*B ppt_xB ppt_y=@0BBAApBBB><*!D?' =%(D' =%(D' =A@BBBB0B%(D' =1:Bhidden*o3>+B#style.visibility<*!%(+p+0+!&  ++0+!&  +7 66pE'6(  2  08N% T Tomemos en cada Complejo de la Cadena transportadora de electrones el donador inicial de electrones y el aceptor final de electrones : :3| 0   #"."xxxxxx0  ~ B&  ?"`    B @` | BT&  ?"`p   S+ 1,130  @` z B &  ?"` p  S+ 0,815  @` x B&  ?"`p   O2.   @` v BT&  ?"` p  S- 0,315  @` t B&  ?"`   jNADH  @` r B&  ?"`   r Total I - IV    @` e B&  ?"`   q Succinato     @` c B& ?0    Citocromo c  "    @` a BL& ?0  q Ubiquinol     @` _ B& ?  q Succinato     @` ] B& ?  jNADH  @` [ B) ?0 mDonador  @` > B )  ?"`p   S+ 0,784  @` < B@) ?p0   S+ 0,561  @` : Bx ) ?p 0  S+ 0,209  @` 8 BX) ?p   S+ 0,014  @` 6 B|2) ?p   S+ 0,360  @` 4 B=) ?p0  DE0:   @` ! BHG)  ?"`    B @`   B P)  ?"` p  S+ 0,815  @`  B@Z)  ?"`p   O2.   @`  Bc)  ?"` p  S+ 0,031  @`  Bl)  ?"`   s Total II - IV   @`  Bu) ? 0   B @`  B,~) ? 0 p  S+ 0,815  @`  B\) ?p0  v O2$   @`  B) ?0 p  S+ 0,254  @`  B`) ?0   hIV  @`  BT) ? 0  B @`  B) ? p0  S+ 0,254  @`  B) ?p 0   Citocromo c  "    @`  B,) ?p0  ]+ 0,045$  @`  B\) ?0  iIII  @`  B<) ?   B @`  B) ? p ]+ 0,045$  @`  BH) ?p   q Ubiquinol     @`  B) ? p S+ 0,031  @`  B) ?  hII  @`   B* ?   D  @`   B * ? p  ]+ 0,045$  @`   B* ?p  q Ubiquinol     @`   B* ?p  S- 0,315  @`   Bh&* ?  gI  @`  B0* ? 0 DG0:   @`  B<* ? 0p E0.   @`  BD* ?p0  mAceptor  @`  B,* ?0p uE0$   @`  B X* ?0 nComplejo    @``B " 0o ?00ZB # s *1 ?ZB $ s *1 ?  ZB % s *1 ?ZB & s *1 ?0 0 ZB ' s *1 ?  `B ( 0o ?  `B ) 0o ?0 ZB * s *1 ?0 ZB + s *1 ?p0p ZB , s *1 ? 0 ZB - s *1 ?p0p `B . 0o ?0 ZB 5 s *1 ? 0  ZB \ s *1 ?0 ZB s s *1 ?  s  <,^* F Realizado por Dr. A. Martnez-Conde & Dra P. Mayor Dep. Bioqumica y Biologa Molecular Fac. Medicina Universidad Complutense de Madrid H&  /  , H  0޽h ? 33___PPT10i.#=I+D=' = @B + <  ;;FG:(  2  0P* T Tomemos en cada Complejo de la Cadena transportadora de electrones el donador inicial de electrones y el aceptor final de electrones : :6| 0  G #"."xxxxxx0 K  Bh*  ?"`    - 52.12 Kcal mol-1. H       @`  B*  ?"`p   S+ 1,130  @`  B*  ?"` p  S+ 0,815  @`  BL*  ?"`p   O2.   @`  B*  ?"` p  S- 0,315  @`   B*  ?"`   jNADH  @`   B*  ?"`   r Total I - IV    @`   B*  ?"`   q Succinato     @`   B* ?0    2 Citocromo c.    @`   B* ?0  q Ubiquinol     @`  B* ?  q Succinato     @`  B* ?  jNADH  @`  B* ?0 mDonador  @`  B*  ?"`p   S+ 0,784  @`  B+ ?p0   S+ 0,561  @`  B* ?p 0  S+ 0,209  @`  B+ ?p   S+ 0,014  @`  B+ ?p   S+ 0,360  @`  B)+ ?p0  DE0:   @`K  B#+  ?"`    - 36.16 Kcal mol-1. H       @`  B,?+  ?"` p  S+ 0,815  @`  BI+  ?"`p   O2.   @`  BB+  ?"` p  S+ 0,031  @`  B[+  ?"`   s Total II - IV   @`3  B]+ ? 0   - 25.87 Kcal mol-1$ H       @`  Bo+ ? 0 p  S+ 0,815  @`  B$j+ ?p0  v O2$   @`  B + ?0 p  S+ 0,254  @`   B+ ?0   hIV  @`2 ! BD+ ? 0  - 9.64 Kcal mol-1$ H      @` " B+ ? p0  S+ 0,254  @` # Bġ+ ?p 0   2 Citocromo c.    @` $ B`+ ?p0  ]+ 0,045$  @` % B+ ?0  iIII  @`= & B`+ ?   - 0.65 Kcal mol-1. H       @` ' B + ? p ]+ 0,045$  @` ( B+ ?p   q Ubiquinol     @` ) B+ ? p S+ 0,031  @` * B+ ?  hII  @`2 + B4+ ?   - 16.57 Kcal mol-1$ H      @` , B, ? p  ]+ 0,045$  @` - B+ ?p  q Ubiquinol     @` . B, ?p  S- 0,315  @` / BT, ?  gI  @` 0 B), ? 0 DG0:   @` 1 B4, ? 0p E0.   @` 2 B=, ?p0  mAceptor  @` 3 BlG, ?0p uE0$   @` 4 BP, ?0 nComplejo    @``B 5 0o ?00ZB 6 s *1 ?ZB 7 s *1 ?  ZB 8 s *1 ?ZB 9 s *1 ?0 0 ZB : s *1 ?  `B ; 0o ?  `B < 0o ?0 ZB = s *1 ?0 ZB > s *1 ?p0p ZB ? s *1 ? 0 ZB @ s *1 ?p0p `B A 0o ?0 ZB B s *1 ? 0  ZB C s *1 ?0 ZB D s *1 ?   E 0hW, 0 !Solo realizamos el clculo cuando el nmero de electrones de los pares donador y aceptor es el mismo para el valor del potencial redox estandar dado en la tabla.H     s F <\, F Realizado por Dr. A. Martnez-Conde & Dra P. Mayor Dep. Bioqumica y Biologa Molecular Fac. Medicina Universidad Complutense de Madrid H&  /  , H  0޽h ? 33___PPT10i.#=I+D=' = @B +5  L D   (    0?,  @ NLa Variacin de energa libre estandar en el proceso de transferencia de 2 electrones desde el NADH hasta el O2 es aproximadamente - 52.12 Kcal mol-10n%b  h       6, P A{La Variacin de energa libre estandar de la reaccin de sntesis de ATP a partir de ADP y de Pi es de + 7.33 Kcal mol-1&|_|  8         0\, p^  Cuantas molculas de ATP se podran sintetizar a partir de ADP y de Pi si se aprovechase toda la energa de la transferencia de estos 2 electrones ? 52 / 7.33 = 7.11 , la energa es suficiente para para producir 7 molculas de ATP&GHF     2  0$, `   En la prctica se producen 3 molculas de ATP. Por ello se dice frecuentemente que la eficiencia del proceso es de 3 x 100 / 7 = 43%    0, p   B Es verdad que el resto se  pierde en forma de calor ? . Decir esto no sera exacto, puesto que las estimaciones que acabamos de realizar se han hecho utilizando valores de Variacin de energa libre estandar, y por lo tanto no son las reales de la mitocondria. nicamente deben tomarse como una aproximacin al problema, y de ah que hablemos de estimacin mas que de clculo.||{ s   <Н, F Realizado por Dr. A. Martnez-Conde & Dra P. Mayor Dep. Bioqumica y Biologa Molecular Fac. Medicina Universidad Complutense de Madrid H&  /  , H  0޽h ? 33___PPT10i.#BW.+D=' = @B +7Y NXFX(0 W(  ( ( 0, T < Como se produce la transferencia de energa desde la Cadena Transportadora de Electrones ( Complejos I, II, III y IV ) hasta el Complejo V ( F0F1 ATPasa )?.L .    ( 0,  4Como ya hemos sealado anteriormente, la Cadena Transportadora de Electrones se comporta como un gran sistema de bombeo de protones, de tal forma que tres de los cuatro complejos ( I, III y IV ) se comportan como Bombas de protones. 8K8 P  ( 0  t%h 0p0v  (3 " T ( c $X99?0p0v B  ( 3 H B  ( 3    ( B)CADE4F A A)3)!)  !3 AA @    `E B  ( 3 ? n B  ( 3    ( B)CADE4F A A)3)!)  !3 AA @    `  E  ( zBCrDEFrrr @`   ( zBCrDEFrrr @`P   ( B*CADE4F A A*3*!*  !3 AA @    `  E  ( zBCrDEFrrr @`}  ( zBCrDEFrrr @`!  ( B*CADE4F A!A*3*!*  !3 AA @    `OD E  ( zBCsDEFss @`e ( zBCrDEFrr @`% ( B*CADE4F !**!*3 AA A2!  @    `6v+ ( zBCsDEFss @`   ( zBCrDEFrr @` %.  ( B*CADE4F !**!*3!AA A2!  @    `\ vQ B ( 3 & U B ( 3  %  ( B)CADE4F  ))!)3 AA A2!  @    `v  ( zBCsDEFss @` ( zBCrDEFrr @`7%f  ( B*CADE4F  *)!)3 AA A2!  @    `v !( zBCrDEFrrr @`7f  "( zBCrDEFrrr @` B2 #( 3 E  $( zBCrDEFrrr @`c  %( zBCrDEFrrr @`  &( B*C@DE4F @!@*2* *   2 @@ @    `4)E B '( 3 . B (( 3 t  )( B*C@DE4F @!@*2* *!  2 @@ @    `E B *( 3  B +( 3 >  ,( B)C@DE4F @ @)2) )   2 @@ @    `raE B -( 3 %B .( 3 %& /( B)CADE4F  ))!)3 AA A2!  @    `YvI 0( zBCrDEFrr @`% 1( zBCrDEFrr @`%K 2( B)CADE4F  ))!)3 AA A2!  @    `vn 3( zB CrDEF rr @`D%y 4( zB CrDEF rr @`% 5( B*CADE4F  **!*3 AA A2!  @    `v 6( zBCrDEFrr @`% 7( zBCrDEFrr @`[% 8( B*CADE4F !**!*3!AA A2!  @    `vB 9( 3 & B :( 3 &B  ;( B)CADE4F A A)2) )   2 AA @    `ven  <( zBCrDEFrrr @` &#  =( zBCrDEFrrr @`i & B2 >( 3   h B ?( 3 # %Q B @( 3  %  A( B)CADE4F  ))!)3 AA A3!  @    ` v  B( zBCrDEFrr @` %  C( zBCrDEFrr @`A%p D( B*CADE4F !** *2!AA @2   @    ` |t%h 0p0v  Q(3 " @P T R( c $X99?0p0v B S( 3 H B T( 3   U( B)CADE4F A A)3)!)  !3 AA @    `E B V( 3 ? n B W( 3    X( B)CADE4F A A)3)!)  !3 AA @    `  E  Y( zBCrDEFrrr @`   Z( zBCrDEFrrr @`P   [( B*CADE4F A A*3*!*  !3 AA @    `  E  \( zBCrDEFrrr @`}  ]( zBCrDEFrrr @`!  ^( B*CADE4F A!A*3*!*  !3 AA @    `OD E  _( zBCsDEFss @`e `( zBCrDEFrr @`% a( B*CADE4F !**!*3 AA A2!  @    `6v+ b( zBCsDEFss @`   c( zBCrDEFrr @` %.  d( B*CADE4F !**!*3!AA A2!  @    `\ vQ B e( 3 & U B f( 3  %  g( B)CADE4F  ))!)3 AA A2!  @    `v  h( zBCsDEFss @` i( zBCrDEFrr @`7%f j( B*CADE4F  *)!)3 AA A2!  @    `v k( zBCrDEFrrr @`7f  l( zBCrDEFrrr @` B2 m( 3 E  n( zBCrDEFrrr @`c  o( zBCrDEFrrr @`  p( B*C@DE4F @!@*2* *   2 @@ @    `4)E B q( 3 . B r( 3 t  s( B*C@DE4F @!@*2* *!  2 @@ @    `E B t( 3  B u( 3 >  v( B)C@DE4F @ @)2) )   2 @@ @    `raE B w( 3 %B x( 3 %& y( B)CADE4F  ))!)3 AA A2!  @    `YvI z( zBCrDEFrr @`% {( zBCrDEFrr @`%K |( B)CADE4F  ))!)3 AA A2!  @    `vn }( zB CrDEF rr @`D%y ~( zB CrDEF rr @`% ( B*CADE4F  **!*3 AA A2!  @    `v ( zBCrDEFrr @`% ( zBCrDEFrr @`[% ( B*CADE4F !**!*3!AA A2!  @    `vB ( 3 & B ( 3 &B  ( B)CADE4F A A)2) )   2 AA @    `ven  ( zBCrDEFrrr @` &#  ( zBCrDEFrrr @`i & B2 ( 3   h B ( 3 # %Q B ( 3  %  ( B)CADE4F  ))!)3 AA A3!  @    ` v  ( zBCrDEFrr @` %  ( zBCrDEFrr @`A%p ( B*CADE4F !** *2!AA @2   @    ` | ( C x, N? Z<P  @ VII(  (  , N? <<P0   WIII(  ( s , N?<PP VIV( DB ( s , E6FG0*H0*Q&RUNV6W&N))? ? `T`T`T`T0*0*`T`TZ$ `TS G G H H@0*`T`T`TPubL @ d I" (  2 ( C x, N? Z<Pp gcit C"  2 ( 3 r0, N?0-<P   UQ s ( <, F Realizado por Dr. A. Martnez-Conde & Dra P. Mayor Dep. Bioqumica y Biologa Molecular Fac. Medicina Universidad Complutense de Madrid H&  /  , H ( 0޽h ? 33___PPT10i.$` +D=' = @B + C{;{4z(  4FKF P  4  0  t%h 0p0v  43 " T 4 c $X99?0p0v B 4 3 H B 4 3   4 B)CADE4F A A)3)!)  !3 AA @    `E B 4 3 ? n B  4 3     4 B)CADE4F A A)3)!)  !3 AA @    `  E   4 zBCrDEFrrr @`    4 zBCrDEFrrr @`P    4 B*CADE4F A A*3*!*  !3 AA @    `  E  4 zBCrDEFrrr @`}  4 zBCrDEFrrr @`!  4 B*CADE4F A!A*3*!*  !3 AA @    `OD E  4 zBCsDEFss @`e 4 zBCrDEFrr @`% 4 B*CADE4F !**!*3 AA A2!  @    `6v+ 4 zBCsDEFss @`   4 zBCrDEFrr @` %.  4 B*CADE4F !**!*3!AA A2!  @    `\ vQ B 4 3 & U B 4 3  %  4 B)CADE4F  ))!)3 AA A2!  @    `v  4 zBCsDEFss @` 4 zBCrDEFrr @`7%f 4 B*CADE4F  *)!)3 AA A2!  @    `v 4 zBCrDEFrrr @`7f  4 zBCrDEFrrr @` B2 4 3 E   4 zBCrDEFrrr @`c  !4 zBCrDEFrrr @`  "4 B*C@DE4F @!@*2* *   2 @@ @    `4)E B #4 3 . B $4 3 t  %4 B*C@DE4F @!@*2* *!  2 @@ @    `E B &4 3  B '4 3 >  (4 B)C@DE4F @ @)2) )   2 @@ @    `raE B )4 3 %B *4 3 %& +4 B)CADE4F  ))!)3 AA A2!  @    `YvI ,4 zBCrDEFrr @`% -4 zBCrDEFrr @`%K .4 B)CADE4F  ))!)3 AA A2!  @    `vn /4 zB CrDEF rr @`D%y 04 zB CrDEF rr @`% 14 B*CADE4F  **!*3 AA A2!  @    `v 24 zBCrDEFrr @`% 34 zBCrDEFrr @`[% 44 B*CADE4F !**!*3!AA A2!  @    `vB 54 3 & B 64 3 &B  74 B)CADE4F A A)2) )   2 AA @    `ven  84 zBCrDEFrrr @` &#  94 zBCrDEFrrr @`i & B2 :4 3   h B ;4 3 # %Q B <4 3  %  =4 B)CADE4F  ))!)3 AA A3!  @    ` v  >4 zBCrDEFrr @` %  ?4 zBCrDEFrr @`A%p @4 B*CADE4F !** *2!AA @2   @    ` |t%h 0p0v  A43 " @P T B4 c $X99?0p0v B C4 3 H B D4 3   E4 B)CADE4F A A)3)!)  !3 AA @    `E B F4 3 ? n B G4 3    H4 B)CADE4F A A)3)!)  !3 AA @    `  E  I4 zBCrDEFrrr @`   J4 zBCrDEFrrr @`P   K4 B*CADE4F A A*3*!*  !3 AA @    `  E  L4 zBCrDEFrrr @`}  M4 zBCrDEFrrr @`!  N4 B*CADE4F A!A*3*!*  !3 AA @    `OD E  O4 zBCsDEFss @`e P4 zBCrDEFrr @`% Q4 B*CADE4F !**!*3 AA A2!  @    `6v+ R4 zBCsDEFss @`   S4 zBCrDEFrr @` %.  T4 B*CADE4F !**!*3!AA A2!  @    `\ vQ B U4 3 & U B V4 3  %  W4 B)CADE4F  ))!)3 AA A2!  @    `v  X4 zBCsDEFss @` Y4 zBCrDEFrr @`7%f Z4 B*CADE4F  *)!)3 AA A2!  @    `v [4 zBCrDEFrrr @`7f  \4 zBCrDEFrrr @` B2 ]4 3 E  ^4 zBCrDEFrrr @`c  _4 zBCrDEFrrr @`  `4 B*C@DE4F @!@*2* *   2 @@ @    `4)E B a4 3 . B b4 3 t  c4 B*C@DE4F @!@*2* *!  2 @@ @    `E B d4 3  B e4 3 >  f4 B)C@DE4F @ @)2) )   2 @@ @    `raE B g4 3 %B h4 3 %& i4 B)CADE4F  ))!)3 AA A2!  @    `YvI j4 zBCrDEFrr @`% k4 zBCrDEFrr @`%K l4 B)CADE4F  ))!)3 AA A2!  @    `vn m4 zB CrDEF rr @`D%y n4 zB CrDEF rr @`% o4 B*CADE4F  **!*3 AA A2!  @    `v p4 zBCrDEFrr @`% q4 zBCrDEFrr @`[% r4 B*CADE4F !**!*3!AA A2!  @    `vB s4 3 & B t4 3 &B  u4 B)CADE4F A A)2) )   2 AA @    `ven  v4 zBCrDEFrrr @` &#  w4 zBCrDEFrrr @`i & B2 x4 3   h B y4 3 # %Q B z4 3  %  {4 B)CADE4F  ))!)3 AA A3!  @    ` v  |4 zBCrDEFrr @` %  }4 zBCrDEFrr @`A%p ~4 B*CADE4F !** *2!AA @2   @    ` | 4 C x. N? Z<P ` `  VII(  4  . N? <<P0   WIII(  4 s `. N?<PP0  VIV( DB 4 s !. E6FG0*H0*Q&RUNV6W&N))? ? `T`T`T`T0*0*`T`TZ$ `TS G G H H@0*`T`T`TPubL`  d I" (  2 4 C xD%. N? Z<PP gcit C"  2 4 3 rp). N?0-<Pp  UQ 2 4 0-. >P p jH+.6 6 2 4 01. >  jH+.6 6 2 4 06. > jH+.6 6 2 4 0:. >  @@ jH+.6 6 2 4 0l?. > jH+.6 6 2 4 0C. >p0 jH+.6 6 2 4 0LH. >  @@ jH+.6 6 2 4 0L. > @ jH+.6 6 2 4 0,Q. >0 jH+.6 6 2 4 0U. > jH+.6 6 2 4 0 Z. > jH+.6 6 2 4 0|^. > 0 jH+.6 6 2 4 0b. >@ ` jH+.6 6 2 4 0\g. >p jH+.6 6 2 4 0k. >0P jH+.6 6 2 4 0 p  jH+.6 6 2 4 0t. >p  jH+.6 6 2 4 0y. >  jH+.6 6 2 4 0}. >0  jH+.6 6 2 4 0. >0P jH+.6 6 2 4 0l. > ` jH+.6 6 2 4 0܊. >P p jH+.6 6  4 <. 0 OPor cada 2 electrones transportados desde el NADH hasta el O2, se bombean 10 H+PN"M   4 <ܓ. @T' RLado P  4 <\. \ RLado N  4 <l. 9 ,$  0 _/Cuatro de ellos son bombeados por el Complejo I/ 2 4 00. > 0P  jH+.6 6 2 4 0. >P p jH+.6 6 2 4 0. >P @`p jH+.6 6 2 4 0h. >   jH+.6 6 2 4 0ز. >`  jH+.6 6 2 4 0H. >0  jH+.6 6 2 4 0. >   jH+.6 6 2 4 0(. > 0P  jH+.6 6 2 4 0. >P @`p jH+.6 6 2 4 0. >0`P jH+.6 6 2 4 0x. >   jH+.6 6  4 <. 0w  s 4 <0. F Realizado por Dr. A. Martnez-Conde & Dra P. Mayor Dep. Bioqumica y Biologa Molecular Fac. Medicina Universidad Complutense de Madrid H&  /  ,  4 <8. 9 ,$ 0 Q!El Complejo III bombea 2 protones! 2 4 0. > p  jH+.6 6 2 4 0. >  jH+.6 6 2 4 0P. >  jH+.6 6 2 4 0. > ` jH+.6 6 2 4 0D. >P p jH+.6 6  4 <8. 0, ,$ 0 P El Complejo IV bombea 2 protones  2 4 0D. > jH+.6 6 H 4 0޽h ? 33bb___PPT10a.$` +%cD]' = @B D[]' = @BA?%,( < +O%,( < +D9' =%(%(Dx9' =%(D' =A@BBBB0B%()?)?)D4' a=.7 BBBBBM -0.05833 0.03076 C -0.06093 0.03076 -0.06336 0.03076 -0.0677 0.03285 C -0.07204 0.03493 -0.07899 0.0414 -0.08454 0.04302 C -0.0901 0.04464 -0.09618 0.04302 -0.10156 0.04302 C -0.10694 0.04302 -0.10711 0.04533 -0.11684 0.04302 C -0.12656 0.04071 -0.14913 0.03285 -0.15989 0.02868 C -0.17065 0.02406 -0.17447 0.02151 -0.18142 0.01643 C -0.18836 0.01134 -0.19357 0.00371 -0.20156 -0.00208 C -0.20954 -0.00786 -0.22048 -0.01364 -0.22916 -0.0185 C -0.23784 -0.02335 -0.25121 -0.02381 -0.25381 -0.03075 C -0.25642 -0.03769 -0.2467 -0.05087 -0.24461 -0.05943 C -0.24253 -0.06799 -0.24375 -0.07701 -0.24149 -0.08209 C -0.23923 -0.08718 -0.23715 -0.08441 -0.23072 -0.09019 C -0.2243 -0.09597 -0.21059 -0.10406 -0.20295 -0.11678 C -0.19531 -0.1295 -0.20781 -0.14662 -0.18454 -0.16604 C -0.16128 -0.18547 -0.09739 -0.22155 -0.06302 -0.23357 C -0.02864 -0.2456 -0.00868 -0.23704 0.02153 -0.23774 C 0.05174 -0.23843 0.09063 -0.23473 0.11858 -0.23774 C 0.14653 -0.24074 0.16494 -0.25416 0.18924 -0.25624 C 0.21355 -0.25832 0.24879 -0.25809 0.26476 -0.24999 C 0.28073 -0.2419 0.27935 -0.22062 0.28473 -0.20698 C 0.29011 -0.19333 0.29601 -0.18246 0.29705 -0.16813 C 0.2981 -0.15379 0.29462 -0.13251 0.2908 -0.12095 C 0.28698 -0.10938 0.28004 -0.10568 0.27396 -0.09828 C 0.26789 -0.09111 0.25869 -0.08741 0.254 -0.07793 C 0.24931 -0.06845 0.24775 -0.05365 0.24619 -0.04093 C 0.24462 -0.02821 0.24844 -0.01503 0.24462 -0.00208 C 0.2408 0.01064 0.2283 0.02776 0.2231 0.03493 C 0.21789 0.0421 0.2198 0.03955 0.21389 0.04094 C 0.20799 0.04233 0.1974 0.04279 0.18768 0.04302 C 0.17796 0.04325 0.16667 0.0488 0.15539 0.04302 C 0.1441 0.03724 0.13091 0.02244 0.12014 0.0081 C 0.10938 -0.00647 0.09636 -0.03445 0.0908 -0.04509 C 0.08525 -0.05573 0.0915 -0.04232 0.08629 -0.05527 C 0.08108 -0.06822 0.07066 -0.1117 0.06007 -0.12303 C 0.04948 -0.13459 0.0375 -0.12627 0.0231 -0.12511 C 0.00869 -0.12395 -0.01354 -0.12257 -0.02604 -0.11678 C -0.03854 -0.111 -0.04687 -0.09828 -0.05225 -0.09019 C -0.05763 -0.08209 -0.05572 -0.07562 -0.05833 -0.06776 C -0.06093 -0.05989 -0.06232 -0.05457 -0.0677 -0.04301 C -0.07309 -0.03145 -0.0835 -0.0067 -0.09062 0.00209 C -0.09774 0.01088 -0.10659 0.00717 -0.11076 0.01018 C -0.11493 0.01319 -0.11319 0.01689 -0.11527 0.02013 C -0.11736 0.02383 -0.11979 0.02915 -0.12309 0.03076 C -0.12638 0.03238 -0.11892 0.04441 -0.13524 0.03076 C -0.15156 0.01689 -0.20173 -0.02636 -0.22152 -0.05134 C -0.24131 -0.07631 -0.24843 -0.09944 -0.25381 -0.11887 C -0.2592 -0.13829 -0.26302 -0.15425 -0.25381 -0.16813 C -0.24461 -0.182 -0.22135 -0.1901 -0.19843 -0.20282 C -0.17552 -0.21554 -0.14427 -0.23704 -0.11684 -0.24398 C -0.0894 -0.25092 -0.06979 -0.24259 -0.03385 -0.24398 C 0.00209 -0.24537 0.06042 -0.25115 0.09844 -0.25208 C 0.13646 -0.253 0.1691 -0.253 0.19393 -0.24999 C 0.21875 -0.24699 0.23334 -0.24629 0.24775 -0.23357 C 0.26216 -0.22085 0.2757 -0.19449 0.28004 -0.17414 C 0.28438 -0.15379 0.27882 -0.12997 0.27396 -0.11077 C 0.2691 -0.09158 0.2573 -0.07585 0.25087 -0.05943 C 0.24445 -0.04301 0.24358 -0.02821 0.23542 -0.01225 C 0.22726 0.00371 0.21337 0.02568 0.20157 0.03678 C 0.18976 0.04765 0.17969 0.05389 0.16476 0.0532 C 0.14983 0.0525 0.13698 0.0384 0.11233 0.03285 C 0.08768 0.02706 0.03577 0.02406 0.01702 0.01851 C -0.00173 0.01296 -0.00086 0.00648 -4.72222E-6 9.3062E-6 * 3>*B ppt_xB ppt_y=0BBaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaA<*4D' =A@BBBB0B%()?)?)DP'  N=.7 BBBBBM -0.03386 0.03492 C -0.04775 0.0266 -0.06146 0.01827 -0.0691 0.00833 C -0.07674 -0.00162 -0.08611 -0.01249 -0.08004 -0.02451 C -0.07396 -0.03654 -0.04479 -0.05712 -0.03229 -0.0636 C -0.01979 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0.06568 C 0.0493 0.07077 0.04427 0.08256 0.03854 0.08603 C 0.03281 0.0895 0.02777 0.08742 0.02309 0.08603 C 0.0184 0.08465 0.01823 0.08164 0.01076 0.07794 C 0.0033 0.07424 -0.01563 0.06938 -0.02153 0.0636 C -0.02743 0.05782 -0.02761 0.05042 -0.02448 0.04302 C -0.02136 0.03562 -0.00695 0.02567 -0.00295 0.0185 C 0.00104 0.01133 0.00052 0.00555 -2.77778E-7 -3.52451E-6 *3>*B ppt_xB ppt_y=y0BBgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaA<*4DL' =A@BB@BB0B%()?)?)BD' =.K7 BBBBB]M -3.33333E-6 -1.60962E-6 L 0.04167 -0.51064 *3>*B ppt_xB ppt_y=@0BBAApBB<B1<*4DP' =A@BB@BB0B%()?)?)BD' =.O7 BBBBBaM 3.33333E-6 -2.44218E-6 L 3.33333E-6 -0.52174 *3>*B ppt_xB ppt_y=@0BBAApBBB<*4DN' =A@BB@BB0B%()?)?)BD' =.M7 BBBBB_M 1.11022E-16 -3.27475E-6 L -0.00833 -0.52174 *3>*B ppt_xB ppt_y=@0BBAApBBB<*4Dt' =%(D' =%(DR' =A@BBB B0B%(D' =-6B'blinds(horizontal)*<3<*4D' =1:Bhidden*o3>+B#style.visibility<*4%(D>' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*4%(D' =-m6Bbox(in)*<3<*4DL' =A@BB@BB0B%()?)?)D' =.K7 BBBBB]M -3.33333E-6 -1.60962E-6 L 0.04167 -0.51064 *3>*B ppt_xB ppt_y=@0BBAApBB<B1<*4D6' =A@BB@BB0B%()?)?)Dm' =.57 BBBBBGM 0.0 -1.60962E-6 L 0.05 -0.61054 *3>*B ppt_xB ppt_y=@0BBAApBB<BL<*4DB' =A@BB@BB0B%()?)?)Dy' =.A7 BBBBBSM 3.33333E-6 8.88067E-7 L 0.05 -0.57724 *3>*B ppt_xB ppt_y=@0BBAApBB<B7Ɠ<*4DH' =A@BB@BB0B%()?)?)D' =.G7 BBBBBYM 3.33333E-6 1.11111E-6 L 0.06666 -0.47778 *3>*B ppt_xB ppt_y=@0BBAApBB=BJt<*4D ' =%(D ' =%(DR' =A@BBB B0B%(D' =-6B'blinds(horizontal)*<3<*4D' =1:Bhidden*o3>+B#style.visibility<*4%(DT' =A@BBB B0B%(D' =1:Bvisible*o3>+B#style.visibility<*4%(D' =-6B'blinds(horizontal)*<3<*4DP' =A@BB@BB0B%()?)?)D' =.O7 BBBBBaM 3.33333E-6 -2.44218E-6 L 3.33333E-6 -0.52174 *3>*B ppt_xB ppt_y=@0BBAApBBB<*4DR' =A@BB@BB0B%()?)?)D' =.Q7 BBBBBcM -3.33333E-6 5.78035E-8 L -3.33333E-6 -0.52162 *3>*B ppt_xB ppt_y=@0BBAApBBBʈ<*4D ' =%(D ' =%(DR' =A@BBB B0B%(D' =-6B'blinds(horizontal)*<3<*4D' =1:Bhidden*o3>+B#style.visibility<*4%(DT' =A@BBB B0B%(D' =1:Bvisible*o3>+B#style.visibility<*4%(D' =-6B'blinds(horizontal)*<3<*4DN' =A@BB@BB0B%()?)?)D' =.M7 BBBBB_M 1.11022E-16 -3.27475E-6 L -0.00833 -0.52174 *3>*B ppt_xB ppt_y=@0BBAApBBB<*4DJ' =A@BB@BB0B%()?)?)D' =.I7 BBBBB[M 3.33333E-6 1.79191E-6 L -0.00834 -0.52162 *3>*B ppt_xB ppt_y=@0BBAApBBBʈ<*4+(+0+40  ++0+40  ++0+40  ++0+40  ++0+40  ++0+40  ++0+40  ++0+40  ++0+40  ++0+40  ++0+40  ++0+40  ++0+40  ++0+40  ++0+40  ++0+40  ++0+40  ++0+40  ++0+40  +' :U2U t9PT(  8 8 <x-0 0w  s 8 <d/0 F Realizado por Dr. A. 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P  ^e-$  2 9 <0 C"?PP   ^e-$  2 9 61 >@  ,$@   0 jH+.6 6 2 9 61 > ,$@   0 jH+.6 6 12 9 C x 1 N?0-<P\@ G ` ,$@   0 UQ XB 9@ 0D)P  9 < 1 | CICLO Q, sitios Q0 y Qi6"  H 8 0޽h ? 33++___PPT10m+.$` +A0DI)' = @B D)' = @BA?%,( < +O%,( < +Dk' =%(D' =%(D' =A@BBBB0B%()?)?D' =.7 BBBBBM -0.04114 0.04231 C -0.05451 0.03607 -0.06788 0.03006 -0.07448 0.01919 C -0.08107 0.00832 -0.07968 -0.01457 -0.08073 -0.02312 *3>*B ppt_xB ppt_y=0BB aaA<*8D' =%(D'' =%(D' =A@BBBB0B%())))?D' =1:Bhidden*o3>+B#style.visibility<*8%(D' =%(D1' =4@BBBB%(D' =1:Bvisible*o3>+B#style.visibility<*|9%(D' =-m6Bbox(in)*<3<*|9D' =%(D' =%(DQ' =4@BBBB%()?)?D' =.m7 BBBBBqM -3.33333E-6 -1.6763E-6 C 0.02865 -1.6763E-6 0.05782 -1.6763E-6 0.07518 0.00046 C 0.09254 0.00093 0.09358 0.00208 0.10434 0.00231 C 0.11511 0.00255 0.129 0.00139 0.13976 0.00116 C 0.15052 0.00093 0.15851 0.00139 0.1691 0.00116 C 0.17952 0.00093 0.19584 0.00116 0.20261 -1.6763E-6 C 0.20955 -0.00115 0.20816 -0.00347 0.21094 -0.00601 C 0.21355 -0.00855 0.21615 -0.01225 0.21927 -0.0148 C 0.22257 -0.01734 0.22761 -0.02011 0.22969 -0.02127 *3>*B ppt_xB ppt_y=N0BBaaaaaaaaApBB=BQ<*|9D ' =%(D' =%(D' =4@BBBB%(D' =1:Bhidden*o3>+B#style.visibility<*|9%(D1' =4@BBBB%(D' =1:Bvisible*o3>+B#style.visibility<*9%(D' =-m6Bbox(in)*<3<*9D' =%(D1' =4@BBBB%(D' =1:Bvisible*o3>+B#style.visibility<*9%(D' =-m6Bbox(in)*<3<*9D' =%(D-' =4@BB?BB%()?)?D' =.I7 BBBBB[M -3.33333E-6 -3.69942E-6 L 0.06719 0.06497 *3>*B ppt_xB ppt_y=@0BBAApBB> =BX=<*9D' =%(D' =%(D' =4@BBBB%(D' =1:Bhidden*o3>+B#style.visibility<*9%(D>' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*9%(D' =-m6Bbox(in)*<3<*9D>' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*9%(D' =-m6Bbox(in)*<3<*9D>' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*9%(D' =-m6Bbox(in)*<3<*9D<' =A@BB@BB0B%()?)?D' =.K7 BBBBB]M 3.05556E-6 -3.52601E-6 L -0.03143 -0.24578 *3>*B ppt_xB ppt_y=@0BBAApBBlBt<*9D<' =A@BB@BB0B%()?)?D' =.K7 BBBBB]M 2.77778E-7 -3.98844E-6 L -0.06024 -0.17572 *3>*B ppt_xB ppt_y=@0BBAApBBwwB<*9D=' =A@BBBB0B%(D' =0l9 CCBB*<3<*9D=' =A@BBBB0B%(D' =0l9 CCBB*<3<*9++0+81  ++0+81  ++0+91  ++0+91  ++0+90  ++0+90  ++0+90  ++0+90  ++0+91  + yq0< (  <FKF P  <  0  t%h 0p0v  <3 " T < c $X99?0p0v B < 3 H B < 3   < B)CADE4F A A)3)!)  !3 AA @    `E B < 3 ? n B  < 3     < B)CADE4F A A)3)!)  !3 AA @    `  E   < zBCrDEFrrr @`    < zBCrDEFrrr @`P    < B*CADE4F A A*3*!*  !3 AA @    `  E  < zBCrDEFrrr @`}  < zBCrDEFrrr @`!  < B*CADE4F A!A*3*!*  !3 AA @    `OD E  < zBCsDEFss @`e < zBCrDEFrr @`% < B*CADE4F !**!*3 AA A2!  @    `6v+ < zBCsDEFss @`   < zBCrDEFrr @` %.  < B*CADE4F !**!*3!AA A2!  @    `\ vQ B < 3 & U B < 3  %  < B)CADE4F  ))!)3 AA A2!  @    `v  < zBCsDEFss @` < zBCrDEFrr @`7%f < B*CADE4F  *)!)3 AA A2!  @    `v < zBCrDEFrrr @`7f  < zBCrDEFrrr @` B2 < 3 E   < zBCrDEFrrr @`c  !< zBCrDEFrrr @`  "< B*C@DE4F @!@*2* *   2 @@ @    `4)E B #< 3 . 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Z<P ` `  VII(  D  > N? <<P0   WIII(  D s p> N?<PP0  VIV( DB D s $> E6FG0*H0*Q&RUNV6W&N))? ? `T`T`T`T0*0*`T`TZ$ `TS G G H H@0*`T`T`TPubL`  d I" (  2 D C xT> N? Z<PP gcit C"  2 D 3 r> N?0-<Pp  UQ 2 D 0> >P p jH+.6 6 2 D 0H> >  jH+.6 6 2 D 0> > jH+.6 6 2 D 0> >  @@ jH+.6 6 2 D 0> > jH+.6 6 2 D 0> >p0 jH+.6 6 2 D 0l> >  @@ jH+.6 6 2 D 0> > @ jH+.6 6 2 D 0L> >0 jH+.6 6 2 D 0B > jH+.6 6 2 D 04B > 0 jH+.6 6 2 D 0 B >@ ` jH+.6 6 2 D 0B >p jH+.6 6 2 D 0tB >0P jH+.6 6 2 D 0xB > p  jH+.6 6 2 D 0 B >p  jH+.6 6 2 D 0B >  jH+.6 6 2 D 0($B >0  jH+.6 6 2 D 0!B >0P jH+.6 6 2 D 0+B > ` jH+.6 6 2 D 01B > jH+.6 6  D <L6B @T' RLado P  D <(:B \ RLado N 2 D 0> > 0P  jH+.6 6 2 D 0@B >P @`p jH+.6 6 2 D 0EB >P @`p jH+.6 6 2 D 0 JB >   jH+.6 6 2 D 0NB >`  jH+.6 6 2 D 0SB >0  jH+.6 6 2 D 0pWB >   jH+.6 6 2 D 0[B >P p jH+.6 6 2 D 0P`B > 0P  jH+.6 6 2 D 0dB >0`P jH+.6 6 2 D 00iB >   jH+.6 6  D <nB 0w  s D <pB F Realizado por Dr. A. Martnez-Conde & Dra P. Mayor Dep. Bioqumica y Biologa Molecular Fac. Medicina Universidad Complutense de Madrid H&  /  , 2 D 0vB >  jH+.6 6 2 D 0d{B >  jH+.6 6 2 D 0B > p  jH+.6 6 2 D 0DB >P p jH+.6 6 2 D 0B > jH+.6 6  D 0hB   DInhibidores del Transporte de electrones del Complejo II : CarboxinaEE";   D <B @@,$  0 [ CARBOXINA 3  B D 0(3 H,$D   0jz    D @ ` ,$@  02 D 6B C"? P  ^e-$  2 D 6 B C"?PP   ^e-$  6F    D  2 D 6|B C"? P  ^e-$  2 D 6ģB C"?PP   ^e-$  2 D 0B >  jH+.6 6 2 D 0B > p  jH+.6 6 2 D 0tB >` jH+.6 6 2 D 0B >P p jH+.6 6 2 D 0TB >` jH+.6 6 2 D 0ľB > ` jH+.6 6 2 D 04B > jH+.6 6 H D 0޽h ? 33yy___PPT10y.$` +Dtu' = @B D/u' = @BA?%,( < +O%,( < +DA' =%(%(DA' =%(D' =4@BBBB%()?)?)D' =.7 BBBBBM -0.04548 -0.11214 C -0.04548 -0.14913 -0.04531 -0.18613 -0.04392 -0.20925 C -0.04253 -0.23237 -0.05121 -0.23653 -0.0375 -0.25156 C -0.02378 -0.26659 0.02205 -0.29202 0.03872 -0.30012 C 0.05539 -0.30821 0.04879 -0.30012 0.0625 -0.30012 C 0.07622 -0.30012 0.10348 -0.30012 0.12118 -0.30012 C 0.13889 -0.30012 0.13802 -0.29757 0.16893 -0.30012 C 0.19983 -0.30266 0.25348 -0.31353 0.30695 -0.31492 C 0.36042 -0.3163 0.43872 -0.31422 0.48941 -0.30867 C 0.54011 -0.30312 0.59132 -0.28578 0.61164 -0.28116 *3>*B ppt_xB ppt_y=)0BBaaaaaaaaaA<*DD' =A@BBBB0B%()?)?)D4' a=.7 BBBBBM -0.05833 0.03076 C -0.06093 0.03076 -0.06336 0.03076 -0.0677 0.03285 C -0.07204 0.03493 -0.07899 0.0414 -0.08454 0.04302 C -0.0901 0.04464 -0.09618 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0.2783 -0.19815 C 0.31823 -0.2 0.4099 -0.22081 0.44184 -0.22566 C 0.47379 -0.23052 0.46077 -0.22636 0.47049 -0.22774 C 0.48021 -0.22913 0.49271 -0.23306 0.50035 -0.23422 C 0.50816 -0.23537 0.51042 -0.23954 0.5165 -0.23422 C 0.52257 -0.2289 0.52587 -0.20971 0.53716 -0.20231 C 0.54844 -0.19491 0.56858 -0.19191 0.58473 -0.18983 C 0.6007 -0.18774 0.60782 -0.19029 0.63386 -0.18983 C 0.65973 -0.18936 0.7099 -0.18497 0.74028 -0.18751 C 0.77066 -0.19006 0.8007 -0.20185 0.8165 -0.20462 C 0.8323 -0.2074 0.82084 -0.20462 0.83559 -0.20462 C 0.85035 -0.20462 0.89375 -0.20462 0.90539 -0.20462 *3>*B ppt_xB ppt_y=O0BB=aaaaaaaaaaaaaaaaaaaaaaaaaaaaA<*DD6' =A@BB@BB0B%()?)?)Dm' =.57 BBBBBGM 0.0 -1.60962E-6 L 0.05 -0.61054 *3>*B ppt_xB ppt_y=@0BBAApBB<BL<*DDB' =A@BB@BB0B%()?)?)Dy' =.A7 BBBBBSM 3.33333E-6 8.88067E-7 L 0.05 -0.57724 *3>*B ppt_xB ppt_y=@0BBAApBB<B7Ɠ<*DDL' =A@BB@BB0B%()?)?)D' =.K7 BBBBB]M -3.33333E-6 -1.60962E-6 L 0.04167 -0.51064 *3>*B ppt_xB ppt_y=@0BBAApBB<B1<*DD8' =A@BB@BB0B%()?)?)Do' =.77 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