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Medicina Universidad Complutense de Madrid H&  /  , x H <A ??p  Z ` |{  H# " V T H c $X99?` |{  H B*C=DE<F&$!*)!49=="=*9*4*@    `r nd  H B,C DELF&qon   **+,+* "  @      `l t2  H B+CDE4F$! +++ !    @    `l n&   H B'C DE4F '''     @    `x b   H BCDETF.`]\@      `    H BCDE4F$!  @    `    H B-C DELF&qon #,,---, #   @      `fV t   H B-C DELF&qon  # ,,---, #   @      `f t  H B-C DELF&qon  ( ,,,--* #   @      `f" tp 2 H 6    ^e-$  2 H 6$   ^e-$  x H <A ??  x H <A ??Y@ x H <A ??@F ' x H <A ?? p  H <*v p k Acidos Grasos"   H <0  WGlucosa  H <L30 &*  ^ Glucolisis 6   H <70 *  UPDH6  H <;`  Z  nCiclo de Krebs6"    H <=@  :  o b oxidacin, 6 6  2 H 6CP @ ^e-$  2 H 60I  ^e-$  2 H 6/ ^e-$  2 H 6O  ^e-$  2 H 6XQ  ^e-$  2  H 6(ZP @ ^e-$   !H 0^` V  YPODER6  "H 0a p \REDUCTOR  6 2 #H 6e ^e-$   $H 0k0@  SCO2 2$  %H 0Ho0q sLos Procesos oxidativos convierten los metabolitos como glucosa o cidos grasos en CO2 + Energa . La Energa se almacena en forma de molculas Reducidas como son NADH y FADH2 , que han recibido 2 electrones durante dichos procesos oxidativos.H      B H s *޽h ? 33"___PPT10.ꐦ+D&' = @B D' = @BA?%,( < +O%,( < +D' =%(D' =%(D6' =4@BBBB%()D' =?B70, 0; .2, .5; .8, .5; 1, 0-g6B fade*<3<*HD' =0l9 BBBB*<3<*H)?D6' =4@BBBB%()D'  =?B70, 0; .2, .5; .8, .5; 1, 0-g6B fade*<3<*HD' =0l9 BBBB*<3<*H)?D6' =4@BBBB%()D' =?B70, 0; .2, .5; .8, .5; 1, 0-g6B fade*<3<*HD' =0l9 BBBB*<3<*H)?Dp' =4@BBBB%())))D' =0l9 CCBB*<3<*HD6' =%(D' =%(D8' =A@BB*BB0B%()?)?)Do' =.77 BBBBBIM 0.00834 0.01111 L 0.0375 0.08333 *3>*B ppt_xB ppt_y=@0BBAApBBn<B?=<*HD' =%(D:' =A@BB*BB0B%()?)?)Dq' =.97 BBBBBKM 0.00417 0.00556 L 0.01667 0.06667 *3>*B ppt_xB ppt_y=@0BBAApBB;BO<<*HD' =%(DT' =A@BBBB0B%()D' =-u6Bdiamond(in)*<3<*HD' =1:Bhidden*o3>+B#style.visibility<*H%(++0+H ++0+H ++0+H +ђ NN``aL\N(  Ls L <F Realizado por Dr. A. Martnez-Conde & Dra P. Mayor Dep. Bioqumica y Biologa Molecular Fac. Medicina Universidad Complutense de Madrid H&  /  , 2 L 0І>0 `P  jH+.6 6 2 L 0>    jH+.6 6 2 L 0>  jH+.6 6 2 L 0(> @`  jH+.6 6 2 L 0> Pp  jH+.6 6  L BLԔC"?pP NIV   L <(ԔC"?   MI   L BԔC"?@ NII   L BԔC"? ?  OIII 2  L 6xpp,$@   0 ^e-$        L#  ,$D  0b ` |{  L# "  T L c $X99?` |{  L B*C=DE<F&$!*)!49=="=*9*4*@    `r nd  L B,C DELF&qon   **+,+* "  @      `l t2  L B+CDE4F$! +++ !    @    `l n&  L B'C DE4F '''     @    `x b  L BCDETF.`]\@      `   L BCDE4F$!  @    `   L B-C DELF&qon #,,---, #   @      `fV t  L B-C DELF&qon  # ,,---, #   @      `f t  L B-C DELF&qon  ( ,,,--* #   @      `f" tp  L 0p 0  YPODER6  L 0   \REDUCTOR  6 2 L 6p `  ^e-$       L# Z,$D  0b ` |{  L# "  T L c $X99?` |{  L B*C=DE<F&$!*)!49=="=*9*4*@    `r nd   L B,C DELF&qon   **+,+* "  @      `l t2  !L B+CDE4F$! +++ !    @    `l n&  "L B'C DE4F '''     @    `x b  #L BCDETF.`]\@      `   $L BCDE4F$!  @    `   %L B-C DELF&qon #,,---, #   @      `fV t  &L B-C DELF&qon  # ,,---, #   @      `f t  'L B-C DELF&qon  ( ,,,--* #   @      `f" tp  (L 0 p 0  YPODER6  )L 0   \REDUCTOR  6 2 *L 6p `  ^e-$       +L# d j,$D  0b ` |{  ,L# "  T -L c $X99?` |{  .L B*C=DE<F&$!*)!49=="=*9*4*@    `r nd  /L B,C DELF&qon   **+,+* "  @      `l t2  0L B+CDE4F$! +++ !    @    `l n&  1L B'C DE4F '''     @    `x b  2L BCDETF.`]\@      `   3L BCDE4F$!  @    `   4L B-C DELF&qon #,,---, #   @      `fV t  5L B-C DELF&qon  # ,,---, #   @      `f t  6L B-C DELF&qon  ( ,,,--* #   @      `f" tp  7L 0) p 0  YPODER6  8L 0)    \REDUCTOR  6 2 9L 6) p `  ^e-$       :L# z,$D 0b ` |{  ;L# "  T L B,C DELF&qon   **+,+* "  @      `l t2  ?L B+CDE4F$! +++ !    @    `l n&  @L B'C DE4F '''     @    `x b  AL BCDETF.`]\@      `   BL BCDE4F$!  @    `   CL B-C DELF&qon #,,---, #   @      `fV t  DL B-C DELF&qon  # ,,---, #   @      `f t  EL B-C DELF&qon  ( ,,,--* #   @      `f" tp  FL 0) p 0  YPODER6  GL 0X)    \REDUCTOR  6 2 HL 6) p `  ^e-$  @ IL 0)   lLa Cadena Transportadora de Electrones bombea protones al espacio intermembrana desde la Matriz mitocondrialmm<B    2 JL 0 ) > p  jH+.6 6 2 KL 0%) >  jH+.6 6 2 LL 0$') > p  jH+.6 6 2 ML 0.) > @`0  jH+.6 6 2 NL 03) > 0  jH+.6 6 2 OL 0 8) >`   jH+.6 6 2 PL 0|<) > p  jH+.6 6 2 QL 0@) > p  jH+.6 6  RL <\E) P  ^O2$   SL <I)  kH2O0  2 TL 6N)  ,$@   0 ^e-$  2 UL 0S) >`0P jH+.6 6 2 VL 0TX) > 0  jH+.6 6 2 WL 0\) > jH+.6 6 2 XL 0([) >0P jH+.6 6 2 YL 0e) > @  jH+.6 6 2 ZL 6Pj)  ,$D   0 ^e-$  2 [L 6n)  p,$@  0 ^e-$  r \L s *I(Pp,$@  0 ]L <u) 7f   ^L <w) V mMatriz Mitocondrial"   `L <{) ` G  oEspacio Intermembrana"  2 aL 0) >  0  jH+.6 6 B L s *޽h ? 33CC___PPT10C.ꐦ+"R-D@' = @B Dz@' = @BA?%,( < +O%,( < +D' =%(D' =%(Da' =4@BBBB%()))D' =1:Bvisible*o3>+B#style.visibility<* L%(D' =-m6Bbox(in)*<3<* LD' =%(D' =4@BBBB%())))?D' =1:Bhidden*o3>+B#style.visibility<* L%(Dq' =4@BBBB%())))?D' =1:Bvisible*o3>+B#style.visibility<*L%(D' =-m6Bbox(in)*<3<*LD' =%(D' =4@BBBB%())))?D' =1:Bhidden*o3>+B#style.visibility<*L%(Dq' =4@BBBB%())))?D' =1:Bvisible*o3>+B#style.visibility<*+L%(D' =-m6Bbox(in)*<3<*+LD' =%(D' =4@BBBB%())))?D' =1:Bhidden*o3>+B#style.visibility<*+L%(D' =%(D' =4@BBBB%())))?D' =1:Bvisible*o3>+B#style.visibility<*:L%(D,$' =%(D' =%(D>' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*TL%(D' =-m6Bbox(in)*<3<*TLD>' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*ZL%(D' =-m6Bbox(in)*<3<*ZLD' =%(DJ' =A@BB*BB0B%()?)?)D' =.I7 BBBBB[M -3.33333E-6 2.08092E-6 L -0.10416 0.09433 *3>*B ppt_xB ppt_y=@0BBAApBBUUUB2A=<*TLDH' =A@BB*BB0B%()?)?)D' =.G7 BBBBBYM -3.33333E-6 2.94798E-6 L 0.01667 0.25526 *3>*B ppt_xB ppt_y=@0BBAApBB<Bt><*ZLD' =%(D>' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<* L%(D' =-m6Bbox(in)*<3<* LD>' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*[L%(D' =-m6Bbox(in)*<3<*[LD1' =4@BBBB%(D' =1:Bvisible*o3>+B#style.visibility<*\L%(D' =-m6Bbox(in)*<3<*\LD' =A@BBBB0B%()?)?)D' =.7 BBBBBM -3.33333E-6 -2.47919E-6 C -0.02725 0.00717 -0.05416 0.01457 -0.07257 0.02359 C -0.09097 0.03261 -0.1033 0.04348 -0.11059 0.05412 C -0.11753 0.06476 -0.11163 0.07794 -0.11614 0.08742 C -0.12066 0.0969 -0.12986 0.10361 -0.13663 0.11101 C -0.14392 0.11841 -0.14861 0.12905 -0.15868 0.13182 C -0.16857 0.1346 -0.1809 0.12836 -0.19757 0.12766 C -0.21423 0.12697 -0.23819 0.12766 -0.2585 0.12766 C -0.27847 0.12766 -0.30139 0.13298 -0.31788 0.12766 C -0.33455 0.12234 -0.34757 0.10592 -0.35816 0.09575 C -0.36875 0.08557 -0.3651 0.07216 -0.38211 0.06661 C -0.39948 0.06106 -0.44323 0.06337 -0.46145 0.06244 C -0.47951 0.06152 -0.47916 0.06129 -0.49114 0.06106 C -0.5033 0.06083 -0.52673 0.06106 -0.53333 0.06106 *3>*B ppt_xB ppt_y=X0BBaaaaaaaaaaaaaApBBBӉ=<*[LD' =A@BBBB0B%()?)?)D ' =.7 BBBBBM 3.33333E-6 -5.92044E-7 C -0.05486 0.00532 -0.10973 0.01064 -0.14202 0.01249 C -0.17448 0.01457 -0.17761 0.0155 -0.19445 0.01249 C -0.21077 0.01018 -0.22223 0.00162 -0.2415 -0.00208 C -0.26077 -0.00578 -0.28872 -0.00786 -0.30955 -0.00925 C -0.33073 -0.01064 -0.35434 -0.00856 -0.36736 -0.00925 C -0.38073 -0.00994 -0.37969 -0.01179 -0.3882 -0.01318 C -0.39705 -0.01434 -0.41129 -0.01388 -0.41979 -0.01711 C -0.42743 -0.02035 -0.42223 -0.02544 -0.43716 -0.03261 C -0.45157 -0.03955 -0.49167 -0.05458 -0.50834 -0.05897 C -0.52518 -0.06337 -0.52726 -0.05897 -0.53733 -0.05897 C -0.54757 -0.05897 -0.56198 -0.05897 -0.56962 -0.05897 C -0.57743 -0.05874 -0.57084 -0.05458 -0.58351 -0.05758 C -0.59618 -0.06013 -0.63542 -0.07215 -0.64584 -0.07493 *3>*B ppt_xB ppt_y=X0BBaaaaaaaaaaaaaApBBUUB\e<* LDa' =4@BBBB%())))D' =,54*3>Bfillcolor=@BPB<*\LD' =1:B solid*a3>Bfill.type<*\LD' =1:B true*]3>Bfill.on<*\LD ' =%(D' =%(D8' =A@BB*BB0B%()?)?)Do' =.77 BBBBBIM 0.0 -8.0481E-7 L 0.01667 0.27752 *3>*B ppt_xB ppt_y=@0BBAApBB<B5><*ULD' =%(DL' =A@BB*BB0B%()?)?)D' =.K7 BBBBB]M -3.33333E-6 -3.17919E-6 L -0.00833 0.36625 *3>*B ppt_xB ppt_y=@0BBAApBBB,;><*WLD' =%(DF' =A@BB*BB0B%()?)?)D}' =.E7 BBBBBWM 3.33333E-6 8.51064E-7 L 0.00833 0.32192 *3>*B ppt_xB ppt_y=@0BBAApBB;B>$><*XLD' =%(DN' =A@BBBB0B%()D' =1:Bvisible*o3>+B#style.visibility<*[L%(D' =-m6Bbox(in)*<3<*[L++0+ L)  ++0+ L)  ++0+TL)  ++0+TL)  ++0+UL)  ++0+WL)  ++0+XL)  ++0+ZL)  ++0+ZL)  ++0+[L)  ++0+[L)  ++0+[L)  +w @ (   k  <) p   Cada uno de estos complejos est formado por varias protenas. La composicin y nomenclatura de estos complejos multienzimticos es esta : Complejo I o NADH : Ubiquinona Oxidoreductasa. Complejo II o Succinato : Ubiquinona Oxidoreductasa. Complejo III o Citocromo bc1 o Ubiquinol : citocromo c Oxidoreductasa Complejo IV o Citocromo Oxidasa. Complejo V o ATPasa mitocondrial o F1F0 ATPasa. -3(               s  <) F Realizado por Dr. A. Martnez-Conde & Dra P. Mayor Dep. Bioqumica y Biologa Molecular Fac. Medicina Universidad Complutense de Madrid H&  /  , H  0޽h ? 33___PPT10i.!@Ah+D=' = @B +; ,6$6pMP$ 5(  P P <)  t o5Complejo I o NADH : Ubiquinona Oxidoreductasa. Con sus 42 - 43 subunidades distintas es el mayor de los cinco complejos en tamao. Su tamao es de alrededor de 1 milln de daltons. Una parte de estas subunidades posee grupos prostticos participando en la transferencia de electrones : un FMN y 7 centros SFe.6-            R8  ~ ZPN P RP B ) @  w ^Cys "  `B PB 0Do@ `B PB 0Do`kfB $PB 6ZDo@kfB %PB 6ZDo})fB CPB 6DoX@`B EPB 0Do `A`B FPB 0Do@SfB GPB 6ZDo`SfB HPB 6ZDo ]$2 IP B() } XFe 2 JP <) z QS fB KPB 6DoucfB LPB 6Do  @fB MPB 6Do  c2 NP <)    QS 2 OP <) 6 QS  PP B$) `g ^Cys "   QP B) l ^Cys "   SP B)  ~ e ^Cys "  2 TP <D*   z QS 2 UP B\*  } XFe 2 WP <* )c QS 2 XP < *   QS  \P B* bI ^Cys "  ^B aP@ 6DorXB bP@ 0Do2XB cP@ 0Dom^B dP@ 6ZDo2P^B eP@ 6ZDo/g2 gP <* rL QS ^B hP@ 6Do5^B iP@ 6Dob^B jP@ 6Do52 kP <* R QS 2 lP <* R QS  mP BH"* R9 ^Cys "   nP B&* kR ^Cys "   oP B** P7 ^Cys "  2 pP <.* L QS 2 qP B2* O XFe XB P@ 0Do` ^B P@ 6ZDo  XB ,P 0Do`,^B P@ 6ZDo XB P@ 0Do L ^B P@ 6ZDop02 P <7*    QS 2 P <<* g QS | P T?   2 P B?*  p `  XFe 2 P <D*   <   QS 2 P <H*   Lj  QS 2 P <hG*   J QS 2 P <P*     QS 2 P B    H P 0޽h ? 33___PPT10k.!@Ah+D?' = @B D' = @BA?%,( < +O%,( < +D1' =%(%(D' =%(Da' =4@BB BB%(D' =1:B 0.5*3>%Bstyle.opacity= B PPT<*PD' =-6B image0BIE*v3=2Bopacity: 0.5 BIE<*P+) o g *b$ (  $ $ <T* C"?0 Z Complejo I    rr $ s *I(C"?p@prr $@ s *I(C"? $ <|* C"? PNADH  $ <t* C"?pW ^NAD+   $ <x* C"?ppW QCoQ   $ <T* C"?p _CoQH2  rr  $ s *I(C"?P rr  $@ s *I(C"?p3  $ <T* C"?9   PNADH  $ <0* C"?@'  ^NAD+   $ <* C"?@k'  OFMN  $ <|* C"?9 _  ]FMNH2   $ <* C"?P 7  \FMNH  (8 @`  &$ ? 2 $$ 6\* C"?@P  ^e-$  2 %$ 6* C"?@`   ^e-$   /$ <* C"?p4W  QCoQ  1$ <* C"?0   _CoQH2   3$ <,* C"?x ^h  lCoQ." "  xB 5$ 0DԔC"? `p xB 6$ 0DԔC"?P `pP rr J$@ s *I(C"?@ <L @`  K$#   2 L$ 6L* C"?@P  ^e-$  2 M$ 6* C"?@`   ^e-$  s N$ < * F Realizado por Dr. A. Martnez-Conde & Dra P. Mayor Dep. Bioqumica y Biologa Molecular Fac. Medicina Universidad Complutense de Madrid H&  /  ,  R$ < * G[H   ~"Otros seis centros ferrosulfurados##"  6F Pp S$  2 T$ 6* C"?P ^e-$  2 U$ 6+ C"?Pp ^e-$   W$ B+ C"?I 0  SFe oxi*0     Y$ B* C"?0 w   wSFe red*"  L 0 t [$# s zr \$ s *I(C"?0 $pzr ]$B s *I(C"?  t>N @`  ^$ @  2 _$ 6+ C"?@P  ^e-$  2 `$ 6,+ C"?@`   ^e-$  xr a$ 0I(C"?g  b$ <t+  ` t   N2x H $ 0޽h ?R$ 33UM___PPT10-.!@Ah+D' = @B D' = @BA?%,( < +O%,( < +D' =%(%(D{' =%(D#' =4@BBBB%(